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Hypercalcemia in patients with advanced chronic renal failure not yet requiring dialysis.

Abstract
Six patients with progressive chronic renal failure not yet requiring dialysis and not consuming supplemental calcium or vitamin D developed hypercalcemia. Three had proven and 1 suspected tertiary hyperparathyroidism, 1 parathyroid carcinoma and 1 aplastic bone. None of the 3 patients who underwent bone biopsy had heavy bone aluminum staining. The patients with proven parathyroid-mediated hypercalcemia had marked elevation of C-terminal parathyroid hormone and alkaline phosphatase values and, when performed, radiographs consistent with osteitis fibrosa. When these findings are absent or the diagnosis is otherwise uncertain, a bone biopsy may provide a definitive diagnosis and guide management.
AuthorsA Greenberg, B M Piraino, F J Bruns
JournalAmerican journal of nephrology (Am J Nephrol) Vol. 9 Issue 3 Pg. 205-10 ( 1989) ISSN: 0250-8095 [Print] Switzerland
PMID2757079 (Publication Type: Journal Article)
Topics
  • Adult
  • Bone and Bones (pathology)
  • Female
  • Humans
  • Hypercalcemia (blood, etiology, pathology)
  • Hyperparathyroidism, Secondary (complications, pathology, surgery)
  • Kidney Failure, Chronic (complications)
  • Male
  • Middle Aged
  • Retrospective Studies

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