HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Muscle necrosis by N-methylated p-phenylenediamines in rats: structure-activity relationships and correlation with free-radical production in vitro.

Abstract
Certain derivatives of p-phenylenediamine have been shown to cause necrosis of cardiac and skeletal muscle in rats; in vitro, such compounds are known to autoxidize to the corresponding radical cations, with concomitant formation of oxygen free-radicals. In the present study, the autoxidation rates of p-phenylenediamine and its N-methyl, dimethyl, trimethyl and tetramethyl derivatives have been determined and compared with the severity of the muscle necrosis induced by each of these compounds in rats. A close correlation was observed between autoxidation rate in vitro and toxicity in vivo, suggesting that free-radical species may be involved in the initiation of the muscle damage caused by these substances.
AuthorsR Munday, E Manns, E A Fowke, G K Hoggard
JournalToxicology (Toxicology) Vol. 57 Issue 3 Pg. 303-14 (Aug 1989) ISSN: 0300-483X [Print] Ireland
PMID2756530 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Free Radicals
  • Phenylenediamines
  • Hydrogen Peroxide
Topics
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Erythrocytes (metabolism)
  • Female
  • Free Radicals
  • Heart (drug effects)
  • Hydrogen Peroxide (metabolism)
  • Molecular Structure
  • Muscles (drug effects, pathology)
  • Myocardium (pathology)
  • Necrosis
  • Phenylenediamines (toxicity)
  • Rats
  • Rats, Inbred Strains
  • Structure-Activity Relationship

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: