Abstract |
Certain derivatives of p-phenylenediamine have been shown to cause necrosis of cardiac and skeletal muscle in rats; in vitro, such compounds are known to autoxidize to the corresponding radical cations, with concomitant formation of oxygen free-radicals. In the present study, the autoxidation rates of p-phenylenediamine and its N-methyl, dimethyl, trimethyl and tetramethyl derivatives have been determined and compared with the severity of the muscle necrosis induced by each of these compounds in rats. A close correlation was observed between autoxidation rate in vitro and toxicity in vivo, suggesting that free-radical species may be involved in the initiation of the muscle damage caused by these substances.
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Authors | R Munday, E Manns, E A Fowke, G K Hoggard |
Journal | Toxicology
(Toxicology)
Vol. 57
Issue 3
Pg. 303-14
(Aug 1989)
ISSN: 0300-483X [Print] Ireland |
PMID | 2756530
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Free Radicals
- Phenylenediamines
- Hydrogen Peroxide
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Topics |
- Animals
- Chemical Phenomena
- Chemistry
- Erythrocytes
(metabolism)
- Female
- Free Radicals
- Heart
(drug effects)
- Hydrogen Peroxide
(metabolism)
- Molecular Structure
- Muscles
(drug effects, pathology)
- Myocardium
(pathology)
- Necrosis
- Phenylenediamines
(toxicity)
- Rats
- Rats, Inbred Strains
- Structure-Activity Relationship
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