The effect of low-carbohydrates calorie-restricted diet on visceral adipose tissue and metabolic status in psoriasis patients receiving TNF-alpha inhibitors: results of an open label controlled, prospective, clinical study.

Abstract

OBJECTIVE:

TNF alpha inhibitors are usually associated with anthropometric changes over the time, however whether and how the visceral adipose tissue (VAT) is involved in this phenomenon, still remains unclear. Aim of the study is to evaluate if the increases in trunk fat percentage (TF%) and VAT are directly involved in anthropometric changes occurring during treatment, and whether and how a calorie restricted diet could prevent these changes.

MATERIAL AND METHODS:

Twenty patients receiving TNF-alpha inhibitors for psoriasis was evaluated at baseline (T0) and after 24 weeks of therapy (T24), and then compared with 25 patients receiving a combined treatment based on TNF alpha inhibitors and low-carbohydrates calorie-restricted diet.

RESULTS:

TNF-alpha inhibitors do not influence the VAT expression. The combined treatment is associated with a significant decrease in body weight (kg) (p < .0001), BMI (p = .0001), WC (cm) (p < .0001), TF% (p < .0001), VAT (p < .0001), serum levels of triglycerides (mg/dL) (p = .0018) and total cholesterol (mg/dL) (p = .0005).

CONCLUSIONS:

The administration of TNF-alpha inhibitors can induce anthropometric changes after 24 weeks, but it does not cause an increase in VAT. The association between low-carbohydrates calorie-restricted diet and anti-TNF-alpha therapy seems to be able to improve the anthropometric profile of psoriasis patients.

• Authors: A Campanati, E Molinelli, G Ganzetti, K Giuliodori, I Minetti, M Taus, M Catani, E Martina, L Conocchiari, A Offidani
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 28 Issue 3 Pg. 206-212 (May 2017) ISSN: 1471-1753 [Electronic] England
• PMID: 27552000 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Triglycerides
• Tumor Necrosis Factor-alpha
• Cholesterol

Topics

• Adult
• Aged
• Body Mass Index
• Body Weight
• Cholesterol (blood)
• Diet, Carbohydrate-Restricted
• Female
• Humans
• Intra-Abdominal Fat (metabolism)
• Male
• Middle Aged
• Obesity
• Prospective Studies
• Psoriasis (drug therapy, pathology)
• Triglycerides (blood)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, metabolism)