Recovery from sensorineural deafness in Wegener's granulomatosis.

Abstract

Wegener's granulomatosis may present with deafness or other aural symptoms. This report describes two patients with histological evidence of Wegener's granulomatosis who developed reversible sensorineural hearing loss during the course of their illness. The first patient showed complete recovery of a sensorineural hearing loss averaging 50 dB after ten months treatment with cyclophosphamide and high-dose prednisolone. The second patient, who was on maintenance haemodialysis, achieved a 40 dB improvement in sensorineural hearing loss within two weeks of adding cyclophosphamide to pre-existing corticosteroid therapy. These findings suggest that the prognosis of sensorineural hearing loss in Wegener's granulomatosis can be improved with suppression of the vasculitic process by early treatment with combined cytotoxic-immunosuppressive therapy.

• Authors: M R Clements, C D Mistry, A O Keith, R T Ramsden
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 103 Issue 5 Pg. 515-8 (May 1989) ISSN: 0022-2151 [Print] England
• PMID: 2754323 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclophosphamide
• Prednisolone

Topics

• Cyclophosphamide (therapeutic use)
• Deafness (drug therapy, etiology)
• Drug Therapy, Combination
• Female
• Granulomatosis with Polyangiitis (complications, drug therapy)
• Humans
• Middle Aged
• Prednisolone (therapeutic use)