Abstract |
Amino acyl derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal against HeLa cells and in vivo antitumor against sarcoma 180. 15-O-(tert-Butoxycarbonyl(BOC)-glycyl)hitachimycin (2), 15-O-(BOC-beta-alanyl)hitachimycin (4), 15-O-(BOC-(O-tert-Bu)-glutamyl)hitachimycin (6) and 15-O-L-alanylhitachimycin (11) showed comparable in vivo antitumor activity with hitachimycin and the solubility of these compounds was improved.
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Authors | K Shibata, S Satsumabayashi, H Sano, K Komiyama, Z B Yang, A Nakagawa, S Omura |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 42
Issue 7
Pg. 1114-23
(Jul 1989)
ISSN: 0021-8820 [Print] England |
PMID | 2753817
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Polyenes
- stubomycin
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Topics |
- Animals
- Antibiotics, Antineoplastic
(chemical synthesis, metabolism, pharmacology, therapeutic use)
- Bacteria
(drug effects)
- Chemical Phenomena
- Chemistry
- Chromatography, High Pressure Liquid
- HeLa Cells
- Humans
- Magnetic Resonance Spectroscopy
- Molecular Structure
- Polyenes
(chemical synthesis, metabolism, pharmacology, therapeutic use)
- Sarcoma 180
(drug therapy)
- Solubility
- Tumor Cells, Cultured
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