Effect of Psoriatic Arthritis on Treatment Response in Patients With Moderate to Severe Psoriasis.

Abstract

BACKGROUND:

Among patients with moderate-to-severe psoriasis, efficacy, and tolerability of available treatments based on psoriatic arthritis (PsA) history are not well-described.<BR />

OBJECTIVE:

We evaluate disease characteristics and treatment response variation in the moderate-to-severe psoriasis population based on PsA history.<BR />

METHODS:

Simple-measure for assessing psoriasis activity (S-MAPA) was used to retrospectively analyze treatment responses.<BR />

RESULTS:

191 moderate-to-severe psoriatic patients, 58 with and 133 without rheumatologist-diagnosed PsA were analyzed. Regardless of PsA history, S-MAPA improvement was similar with biologic monotherapy (46.2 versus 44.1; <em>P</em>=0.74), traditional systemic monotherapy (62.29 versus 38.12; <em>P</em>=0.22), and combination treatments (64.62 versus 52.71; <em>P</em>=0.40) after 12 weeks. PsA patients on biologic monotherapy experienced a higher infection rate than patients without PsA (0.57% versus 0.19%; <em>P</em>=0.01). PsA patients experienced more adverse events (AEs) associated with traditional systemic monotherapy than biologic monotherapy (3.25 versus 1.04; <em>P</em>=.001).<BR />

LIMITATIONS:

The relatively small PsA cohort was the primary limitation.<BR />

CONCLUSIONS:

Patients with moderate-to-severe psoriasis responded similarly to all treatments independent of PsA history. PsA patients received more overall treatments and more biologic monotherapy prescriptions. PsA patients had a greater infection risk on biologic monotherapy compared to those without PsA, and greater adverse events risk on traditional systemic monotherapy compared to biologic monotherapy.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2016;15(8):917-922.

• Authors: Jacqueline E Greb, Caren Garber, Alice B Gottlieb
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 15 Issue 8 Pg. 917-22 (Aug 01 2016) ISSN: 1545-9616 [Print] United States
• PMID: 27537990 (Publication Type: Journal Article)

Chemical References

• Biological Products

Topics

• Adult
• Aged
• Arthritis, Psoriatic (diagnosis, drug therapy)
• Biological Products (administration & dosage)
• Cross-Sectional Studies
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome