[Cytological and immunological aspects of the antitumor action of polyhexamethylene guanidine in BALB/c mice].

Abstract

Repeated intraperitoneal and intratumor administration of polyhexamethylene guanidine (PMG) in 3 and 5 mg/kg doses to sarcoma 180 bearing mice caused a significant reduction in tumour mass accompanied by increased incidence of diploid and hypodiploid cells. PMG brings about an increase in the number of activated macrophages in the spleen, whereas the response of antibody-producing cells (APC) varies with the dose. A single injection of PMG (1 mg/kg) caused stimulation, but under repeated administration and at higher doses the drug suppressed APC proliferation. The dose-dependent effects of PMG on humoral immunity was due to its specific influence on the spleen L-ornithine decarboxylase activity.

• Authors: E A Baumanis, I A Birska, G K Zakenfeld, V V Volkova, U E Luksha
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 11 Issue 3 Pg. 66-9 ( 1989) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Tsitologicheskiĭ i immunologicheskiĭ aspekty protivoopukholevogo deĭstviia poligeksametilenguanidina u mysheĭ linii BALB/c.
• PMID: 2752947 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Guanidines
• polyhexamethyleneguanidine
• Ornithine Decarboxylase

Topics

• Animals
• Antibody-Producing Cells (drug effects, immunology)
• Antineoplastic Agents (therapeutic use)
• DNA, Neoplasm (analysis, drug effects)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Guanidines (therapeutic use)
• Macrophages (drug effects, immunology)
• Male
• Mice
• Mice, Inbred BALB C
• Neoplasm Transplantation
• Ornithine Decarboxylase (metabolism)
• Sarcoma 180 (drug therapy, immunology, metabolism)
• Spleen (drug effects, enzymology, immunology)