Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies.

Abstract

OBJECTIVE:

The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.

METHODS:

We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS:

The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).

CONCLUSION:

Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

• Authors: Olivia Febvey, Joachim Schüz, Helen D Bailey, Jacqueline Clavel, Brigitte Lacour, Laurent Orsi, Tracy Lightfoot, Eve Roman, Roel Vermeulen, Hans Kromhout, Ann Olsson
• Journal: Journal of occupational and environmental medicine (J Occup Environ Med) Vol. 58 Issue 10 Pg. 1046-1052 (10 2016) ISSN: 1536-5948 [Electronic] United States
• PMID: 27525525 (Publication Type: Journal Article)

Chemical References

• Pesticides

Topics

• Case-Control Studies
• Central Nervous System Neoplasms (epidemiology)
• Child
• Child, Preschool
• Female
• France
• Germany
• Humans
• Male
• Occupational Exposure (adverse effects)
• Parents
• Pesticides (adverse effects)
• Pregnancy
• Prenatal Exposure Delayed Effects (epidemiology)
• Risk Factors
• United Kingdom