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Antitumoral activity of a xanthate compound. II. Therapeutic studies in murine leukemia and tumor models in vivo.

Abstract
The combinations of tricyclodecan-9-yl-xanthogenate (D 609) with undecanoic acid (C11) and D 609 with myristic acid (C14) were tested in 3 rodent tumor models in vivo. D 609 in combination with C11 or C14 did not show antitumoral efficacy in 3-Lewis lung carcinoma (3-LL) growing in syngeneic C57BL6-mice (primary tumor and metastasis) or in WEHI-3B myelomonocytic leukemia growing in Balb/c mice, when given in a dose range lower than the lethal dose for 10% of the treated animals (LD10). In L 1210 mouse lymphoid leukemia growing in CD2F1 mice the combination of D 609/C11 given intraperitoneally in a concentration of 100 mg/kg for more than 1 day effected a significant difference in the survival curves between the control and therapeutic groups in 1 out of 2 experiments. In conclusion, the treatment schedules of D 609/C11 or D 609/C14 used in this study has not revealed significant therapeutic effects in mouse tumors or leukemias in vivo.
AuthorsH D Schick, S Danhauser-Riedl, E Amtmann, R Busch, A Reichert, G Steinhauser, J Rastetter, G Sauer, W E Berdel
JournalCancer letters (Cancer Lett) Vol. 46 Issue 2 Pg. 149-52 (Jul 15 1989) ISSN: 0304-3835 [Print] Ireland
PMID2752384 (Publication Type: Journal Article)
Chemical References
  • Bridged-Ring Compounds
  • Fatty Acids
  • Myristic Acids
  • Norbornanes
  • Thiocarbamates
  • Thiones
  • undecanoic acid
  • tricyclodecane-9-yl-xanthogenate
Topics
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bridged-Ring Compounds (administration & dosage)
  • Fatty Acids (administration & dosage)
  • Female
  • Leukemia L1210 (drug therapy)
  • Leukemia, Experimental (drug therapy)
  • Lung Neoplasms (drug therapy, secondary)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Myristic Acids (administration & dosage)
  • Neoplasms, Experimental (drug therapy)
  • Norbornanes
  • Thiocarbamates
  • Thiones (administration & dosage)

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