A total of 165 patients with
lymphoma, who underwent autoHSCT between the years of 2007 and 2014, were included in this study.
Ferritin levels were used to determine
iron status; the cut-off value was 500 ng/mL. The relationship between
iron overload and survival was assessed by statistical analysis.
RESULTS: The median
ferritin level in the normal
ferritin (ferritin < 500) group was 118 ng/mL (range, 9-494 ng/mL) and in the high-
ferritin group (ferritin ≥ 500), it was 908 ng/mL (range, 503-4549 ng/mL). A total of 64 (38.8%) patients died during follow-up. Of these patients that died, 52 (81.25%) were in the high-
ferritin group, and 12 (18.75%) were in the normal
ferritin group (P ≤ .001). Twelve (14.1%) of 85 patients died in the normal
ferritin group, and 52 (65.0%) of 80 patients died in the high-
ferritin group. The overall mortality was significantly higher in the high-
ferritin group (P < .001). The median overall survival was 42 months (range, 25-56 months) in the normal-
ferritin group and20 months (range, 5-46) in the high-
ferritin group. The difference between the groups was statistically significant (P < .001). The median disease-free survival was 39 months (range, 16-56) in the normal
ferritin group and 10 months (range, 3-29) in the high-
ferritin group. The difference between the groups was statistically significant (P < .001).
CONCLUSION: