Cardiovascular effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol and possible mechanisms involved.

Abstract

Cardiovascular effects of NC-1100 (1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol and possible modes of action were studied in dogs and guinea pigs. 1. In pentobarbital-anesthetized dogs, intravenous administration of NC-1100 (0.05-1.6 mg/kg) induced a dose-dependent fall of blood pressure, a bradycardia followed by temporal tachycardia, a slight and transient stimulation of respiration and a prolongation of the R-R interval with slight augmentations of P, R and T waves in ECG. 2. In pentobarbital-anesthetized dogs, NC-1100 (2.5-80 micrograms/kg) administered to the maxillary and vertebral artery dose-dependently increased the blood flow in the respective artery. 3. Intravenous administration of NC-1100 (0.05-1.6 mg/kg) also exhibited dose-dependent increases of the maxillary and vertebral blood flow, though the increase in maxillary flow was a little reduced at a high dose of 1.6 mg/kg. Intravenous administration of NC-1100 (0.1-1.6 mg/kg) caused a slight increase in the aortic and coronary blood flow, a decrease in renal flow and a slight and transient decrease followed by an increase in femoral flow. 4. In pentobarbital-anesthetized dogs, NC-1100 (1 mg/kg) administered i.v. did not affect responses of blood pressure and heart rate to norepinephrine and isoprenaline (isoproterenol) but slightly inhibited hypotensive responses to acetylcholine. NC-1100 had no effect on hypertension elicited by carotid sinus reflex and on bradycardia by vagus stimulation. NC-1100 slightly inhibited the tachycardia elicited by pre- as well as postganglionic stellate stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: K Kushiku, M Ohba, T Araki, T Mikagi, T Katsuragi, T Furukawa
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 39 Issue 4 Pg. 458-63 (Apr 1989) ISSN: 0004-4172 [Print] Germany
• PMID: 2751731 (Publication Type: Journal Article)

Chemical References

• Piperazines
• Vasodilator Agents
• tamolarizine

Topics

• Animals
• Blood Pressure (drug effects)
• Carotid Arteries (drug effects)
• Dogs
• Electrocardiography
• Female
• Guinea Pigs
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Male
• Papillary Muscles (drug effects)
• Piperazines (pharmacology)
• Reflex (drug effects)
• Regional Blood Flow (drug effects)
• Respiration (drug effects)
• Stellate Ganglion (drug effects)
• Vasodilator Agents (pharmacology)