Abstract | SCOPE: METHODS AND RESULTS: Using LC-MS/MS, enterolactone concentrations were quantified in plasma samples from 2237 participants from the Diet, Cancer and Health cohort. The participants were healthy at enrollment, but were later diagnosed with cancer. At enrollment, participants had blood drawn and completed a food frequency questionnaire and lifestyle questionnaire. Antibiotic use was assessed as reimbursed antibiotic prescriptions up to 12 months before enrollment. Antibiotic use ≤3 months before enrollment was associated with a 41% (Δcrude : -41; 95% CI: -52, -28) lower enterolactone concentration in women and 12% in men (Δcrude : -12; 95% CI: -31, 11), while antibiotic use >3-12 months before enrollment was associated with 26% lower enterolactone in women (Δcrude : -26; 95% CI: -37, -14) and 14% in men (Δcrude : -14; 95% CI: -28, 1). CONCLUSION: Use of antibiotics up to 12 months before enrollment was associated with lower plasma enterolactone levels, especially among women.
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Authors | Anne K Bolvig, Cecilie Kyrø, Natalja P Nørskov, Anne K Eriksen, Jane Christensen, Anne Tjønneland, Knud E Bach Knudsen, Anja Olsen |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 60
Issue 12
Pg. 2712-2721
(12 2016)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 27500753
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Anti-Bacterial Agents
- Lignans
- 4-Butyrolactone
- 2,3-bis(3'-hydroxybenzyl)butyrolactone
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Topics |
- 4-Butyrolactone
(analogs & derivatives, blood)
- Anti-Bacterial Agents
(administration & dosage, adverse effects)
- Body Mass Index
- Cohort Studies
- Exercise
- Female
- Gastrointestinal Microbiome
(drug effects)
- Humans
- Life Style
- Lignans
(administration & dosage, blood)
- Linear Models
- Male
- Middle Aged
- Neoplasms
(blood, diagnosis)
- Nutrition Assessment
- Risk Factors
- Surveys and Questionnaires
- Tandem Mass Spectrometry
- Time Factors
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