[Drug prophylaxis of liver lesions induced by isoniazid and its metabolites].

Abstract

The results of the experiments with use of isoniazid and its metabolites showed that in the liver of rats isoniazid induced albuminous degeneration with stroma inflammation and hepatocyte necrosis, monoacetylhydrazine induced fatty hepatosis, acetylisoniazid induced fatty hepatosis with stroma inflammation and hepatocyte necrosis and isonicotinic acid induced granular degeneration. Piracetam proved to be efficient in fatty hepatosis. Riboxin and dibunol were efficient in hepatitis. The drugs used clinically as liver protectors, i.e. cobamamide, pyridoxal phosphate and methionine had no protective action in liver affections induced by isoniazid whereas catergen, lipamide, dipromonium and methindione even aggravated such affections.

• Authors: G B Sokolova, V P Nikolaev, V I Braude, A V Ziia
• Journal: Problemy tuberkuleza (Probl Tuberk) Issue 5 Pg. 36-40 ( 1989) ISSN: 0032-9533 [Print] Russia (Federation)
• Vernacular Title: Medikamentoznaia profilaktika porazheniĭ pecheni, obuslovlennykh izoniazidom i ego metabolitami.
• PMID: 2748556 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Butylated Hydroxytoluene
• Inosine Diphosphate
• Isoniazid
• Piracetam

Topics

• Animals
• Butylated Hydroxytoluene (pharmacology)
• Chemical and Drug Induced Liver Injury
• Female
• Inosine Diphosphate (pharmacology)
• Isoniazid (adverse effects, metabolism)
• Liver (drug effects)
• Liver Diseases (prevention & control)
• Piracetam (pharmacology)
• Rats