This study was undertaken with a view to assessing the effectiveness and tolerance of
tiropramide hydrochloride in the
premedication of endoscopic rectosigmoidoscopy. The following were considered for this purpose: 1) speed of execution of the procedure; 2) its tolerance; 3) possible complications. The effectiveness of
tiropramide was also examined in uncomplicated
diverticular disease: 1) comparison of execution times for rectosigmoidoscopy before and after
therapy; 2) the evaluation of the reduction in symptomatology. The patients were subdivided into three groups: 1st group submitted to diagnostic rectosigmoidoscopy; 2nd group submitted to therapeutic rectosigmoidoscopy; 3rd group with
diverticular disease. In the first group, execution times were less than 20 minutes in all cases bar 1 and tolerance was good in 27 cases, average in 3. In the second group, times were less than 15 minutes in 6 cases and higher in 4, and tolerance was good in 7 cases and average in 3. In the third group (10 patients), examination execution time was reduced after
therapy in 9 cases and in the same number
pain symptomatology regressed.
Tiropramide proved to be the antispastic of choice in
premedication for rectosigmoidoscopy and an effective
drug in the treatment of uncomplicated
diverticular disease.