[Thyroid hormone anomalies in patients with insulin-dependent diabetes mellitus and circulating antithyroid microsomal antibodies].

Abstract

In insulin-dependent diabetes mellitus (IDDM) several organ-specific autoantibodies are found in addition to pancreatic islet cell autoantibodies. In the present study we researched the presence of thyroid microsomal antibodies (anti-TMS) in 33 young patients with IDDM and evaluated contemporaneously their thyroid function. 5 patients (15.4%) are found with significant levels of circulating anti-TMS, among them 4 (12.1%) were also subclinical hypothyroid. However 6 other patients are found with mildly altered thyroid hormone pattern in absence of circulating anti-TMS. Basal and TRH-stimulated TSH were significantly higher, whereas serum FT4 was significantly lower, in patients with IDDM and circulating anti-TMS than in patients with IDDM but without anti-TMS. These observations indicate a significant incidence of mild or subclinical hypothyroidism in patients with IDDM and anti-TMS. Thus the screening for anti-TMS is recommended in all patients with IDDM, then thyroid hormone pattern of anti-TMS positive patients must be periodically followed.

• Authors: N Custro, V Scafidi, G Costanzo, D Casiglia
• Journal: Minerva medica (Minerva Med) Vol. 80 Issue 5 Pg. 427-30 (May 1989) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Anomalie ormonali tiroidee in pazienti con diabete mellito insulino-dipendente ed anticorpi antitiroidei microsomiali in circolo.
• PMID: 2747968 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Thyrotropin
• Thyroxine

Topics

• Adolescent
• Adult
• Autoantibodies (analysis)
• Child
• Chronic Disease
• Diabetes Mellitus, Type 1 (blood, immunology)
• Female
• Humans
• Male
• Microsomes (immunology)
• Thyroid Gland (immunology)
• Thyrotropin (blood)
• Thyroxine (blood)