The efficacy of intra-alveolar 0.2% chlorhexidine gel on alveolar osteitis: a meta-analysis.

Abstract

OBJECTIVES:

The objective of this meta-analysis was to assess the effect of 0.2% chlorhexidine gel in preventing alveolar osteitis following mandibular third molar extraction(s).

METHODS:

PubMed, Cochrane Library, Embase, Web of Science, Science Direct and the references of identified articles were searched for relevant studies that met our eligibility criteria. Treatment effects were combined by meta-analysis using RevMan 5.3 and Stata 12.0 software.

RESULTS:

We included 11 trials in this meta-analysis. Compared to the control, 0.2% chlorhexidine gel reduced the risk of alveolar osteitis by 62% (RR = 0.38, 95% CI = 0.28-0.53, P < 0.00001) following mandibular third molar extraction(s). The subgroup analysis results indicated that 0.2% chlorhexidine gel reduced the risk of alveolar osteitis after mandibular third molar extraction(s) by 75% (RR = 0.25, 95% CI = 0.11-0.58) and 56% (RR = 0.44, 95% CI = 0.30-0.63) compared to no treatment and placebo, respectively. However, the occurrence of alveolar osteitis following mandibular third molar extraction(s) was not significantly different between 0.2% chlorhexidine gel and 0.12% chlorhexidine mouthwash (RR = 0.24, 95% CI = 0.06-1.00).

CONCLUSION:

The results showed that 0.2% chlorhexidine gel was effective in preventing alveolar osteitis after lower third molar extraction(s).

• Authors: J Zhou, B Hu, Y Liu, Z Yang, J Song
• Journal: Oral diseases (Oral Dis) Vol. 23 Issue 5 Pg. 598-608 (Jul 2017) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 27479137 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Infective Agents, Local
• Gels
• Chlorhexidine

Topics

• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Chlorhexidine (administration & dosage, therapeutic use)
• Dry Socket (etiology, prevention & control)
• Gels
• Humans
• Mandible
• Molar, Third
• Tooth Extraction (adverse effects)