Abstract |
Twenty-seven children with histologically proven malignant histiocytosis were treated in the same institution from January, 1975 to December, 1986 with a combination chemotherapy regimen containing vincristine, cyclophosphamide, doxorubicine, and prednisone. Twenty-two patients achieved complete remission, one partial remission, and four no remission. Eight patients relapsed and were treated with Lomustine ( CCNU), vinblastine, and bleomycin. In seven cases, a second complete remission was obtained. The overall survival rate is 81% at 5 years and the relapse-free survival rate is 54.5% at 5 years. Prognostic factors were fever and age under 10 at diagnosis, which were correlated with a higher incidence of relapse or no remission.
|
Authors | L Brugieres, J M Caillaud, C Patte, C Rodary, A Bernard, C Kalifa, O Hartmann, J Lemerle |
Journal | Medical and pediatric oncology
(Med Pediatr Oncol)
Vol. 17
Issue 3
Pg. 193-6
( 1989)
ISSN: 0098-1532 [Print] United States |
PMID | 2747592
(Publication Type: Journal Article)
|
Chemical References |
- Procarbazine
- Mechlorethamine
- Vincristine
- Doxorubicin
- Cyclophosphamide
- Prednisone
|
Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child
- Child, Preschool
- Cyclophosphamide
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Infant
- Lymphatic Diseases
(drug therapy, pathology)
- Male
- Mechlorethamine
(administration & dosage)
- Prednisone
(administration & dosage)
- Procarbazine
(administration & dosage)
- Prognosis
- Remission Induction
- Vincristine
(administration & dosage)
|