[Appearance of chromosomally normal hemopoiesis during busulfan-induced remission in a case of Ph1 positive chronic myelogenous leukemia].

Abstract

A 33-year-old female was admitted to St. Marianna University hospital in April 1983 for the purpose of examination for leukocytosis. Physical examination revealed a marked splenomegaly. The white cell count was 174 x 10(9)/l. The hemoglobin was 9.0 g/dl and the platelet was 790 x 10(9)/l. Microscopical examination of aspirated specimen of bone marrow revealed hypercellularity with granulocytic hyperplasia. The chromosomal analysis of bone marrow cells showed Philadelphia chromosomes in all metaphases analyzed. The neutrophil alkaline phosphatase activity was reduced. A diagnosis of CML was made. She was treated with busulfan in a dose of 2 mg/day until the white cell count was 14.5 x 10(9)/l. She has been followed without any therapy and clinical remission state has been continued. In April 1985, the chromosomal analysis of bone marrow cells revealed the recovery of normal karyotype hemopoiesis in 57% of metaphases analyzed. These findings of this case suggest that some of Ph1-positive cells may reduce their growth advantage over normal cells without any bone marrow hypoplasia.

• Authors: H Takahira, H Ideguchi, J Hirata, J Nishimura, H Nawata, S Shimizu
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 30 Issue 2 Pg. 251-5 (Feb 1989) ISSN: 0485-1439 [Print] Japan
• PMID: 2746880 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Busulfan

Topics

• Adult
• Busulfan (therapeutic use)
• Female
• Hematopoiesis
• Humans
• Karyotyping
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy, genetics)
• Remission Induction