[Estimation of parental resistance in evaluating the effect of chemical substances on children's health].

Abstract

Proceeding from the experimental study carried out on the model of aniline methemoglobinemia, it was shown that the animals with low aniline-related resistance also had aniline low-resistant posterity during two following generations and vice versa high-resistant animals had the more aniline-resistant posterity. It was determined both by methemoglobin levels and by the number of animals with different methemoglobin levels. According to the degree of aniline-induced methemoglobinemia the correlation among three generations of animals was established.

• Authors: Iu I Prokopenko, V P Il'in
• Journal: Gigiena i sanitariia (Gig Sanit) Issue 3 Pg. 26-8 (Mar 1989) ISSN: 0016-9900 [Print] Russia (Federation)
• Vernacular Title: Ob uchete rezistentnosti organizma roditeleĭ pri otsenke vliianiia khimicheskikh veshchestv na zdorov'e deteĭ.
• PMID: 2744499 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aniline Compounds

Topics

• Aniline Compounds (toxicity)
• Animals
• Disease Models, Animal
• Drug Hypersensitivity (genetics)
• Drug Resistance
• Female
• Male
• Methemoglobinemia (chemically induced, genetics)
• Parents
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats