[The inhibition of esophageal tumor development by the use of the nonsteroidal and steroidal anti-inflammatory preparations indomethacin and dexamethasone].

Abstract

The effects of indomethacin and dexamethasone on carcinogenesis of the esophagus and forestomach were studied in male rats. The rats were treated by N-nitrososarcosine ethyl ester (NSEE) per os in a daily dose of 50 mg/kg body weight for 16 weeks. Indomethacin (25 mg per kg of the food) and dexamethasone (1 mg per kg of the food) were added to food on accomplishing the carcinogen treatment for another 16 weeks, thereafter the animals were sacrificed. NSEE induced the esophagus and forestomach tumors approximately in 90% of cases, mainly papillomas and rarely carcinomas, on the average more than 5 tumors per nat. Indomethacin and dexamethasone were shown to inhibit the development of the NSEE-induced tumors both in the esophagus and forestomach. The both drugs decreased tumor incidence approximately by 20% and tumor multiplicity more than twofold.

• Authors: V G Bespalov, D N Troian, A S Petrov, V A Aleksandrov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1989 Mar-Apr Vol. 52 Issue 2 Pg. 67-70 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Tormozhenie razvitiia opukholeĭ pishchevoda s pomoshch'iu protivovospalitel'nykh preparatov nesteroidnoĭ i steroidnoĭ prirody indometatsina i deksametazona.
• PMID: 2744148 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Carcinogens
• Nitrosamines
• N-nitrososarcosine ethyl ester
• Dexamethasone
• Indomethacin

Topics

• Animals
• Carcinogens
• Dexamethasone (therapeutic use)
• Drug Evaluation, Preclinical
• Esophageal Neoplasms (chemically induced, pathology, prevention & control)
• Esophagus (pathology)
• Indomethacin (therapeutic use)
• Male
• Nitrosamines
• Rats
• Stomach (pathology)
• Stomach Neoplasms (chemically induced, pathology, prevention & control)