Serum carbohydrate antigen 125 concentration as a superior predictor for serosal effusion at diagnosis and a prognostic factor in diffuse large B-cell lymphoma.

Abstract

BACKGROUND:

Carbohydrate antigen 125 (CA-125) is one of the most common used tumor biomarkers in clinical practice. Previous studies showed an association of increased CA-125 levels with advanced characteristics and inferior outcome in non-Hodgkin lymphoma.

OBJECTIVE:

To identify the clinical significance of CA-125 in diffuse large B-cell lymphoma (DLBCL).

METHODS:

We retrospectively analyzed 181 patients with DLBCL with measured serum CA-125 concentration at diagnosis and follow-ups during the courses. Clinical significance of CA-125 was evaluated by assessing the association between CA-125 levels and clinical characteristics.

RESULTS:

CA-125 levels on admission were positively correlated with serum lactate dehydrogenase, β2-microglobulin (β2-MG), serum ferritin (SF) and cavity effusion, while negatively correlated with serum albumen (ALB). During the courses, CA-125 levels were positively correlated with β 2-MG, SF and effusion, and negatively correlated with ALB. A better correlation between effusion and CA-125 levels was observed. Using a cut-off value > 50.39 U/ml gave a sensitivity of 73.8% and a specificity of 92.1% for the indication of effusion at diagnosis, while during the courses the sensitivity was much lower. On the prognostic role of CA-125, we found prognostic relevance on progression-free survival (PFS) but not on overall survival (OS).

CONCLUSIONS:

Our study revealed limited usefulness of CA-125 concentration at diagnosis and follow-ups in DLBCL.

• Authors: Jia-Zhu Wu, Tian Tian, Ying Huang, Jin-Hua Liang, Yi Miao, Li Wang, Ji Xu, Xiao-Yan Qu, Lei Fan, Jian-Yong Li, Wei Xu
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 17 Issue 2 Pg. 205-12 (Jul 08 2016) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 27434288 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CA-125 Antigen

Topics

• Adult
• Aged
• Biomarkers, Tumor
• CA-125 Antigen (blood)
• Female
• Humans
• Lymphoma, Large B-Cell, Diffuse (blood, diagnosis, drug therapy, mortality)
• Lymphoma, Primary Effusion (blood, diagnosis, drug therapy, mortality)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Survival Analysis