Effect of V-9-M, a peptide fragment derived from procholecystokinin, on memory processes in the rat.

Abstract

It has been reported that a nonapeptide (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) called V-9-M is produced from procholecystokinin in the brain. Since this peptide is particularly abundant in the hippocampus, septum, and amygdala. V-9-M may be involved in memory processes. The present study was attempted to observe the effect of V-9-M on memory processes of rat performing a one-trial passive avoidance task and a platform jumping active avoidance task. The results indicate that injection of V-9-M into the lateral ventricle of the rat prevents experimental amnesia induced by electroconvulsive shock in passive avoidance testing, and that this effect is not significantly affected by cholecystokinin-8 antagonists. V-9-M also causes a long-lasting enhancement of memory in the active avoidance task. These results suggest that V-9-M may participate in the facilitation of memory.

• Authors: A Takashima, S Itoh
• Journal: Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 67 Issue 3 Pg. 228-31 (Mar 1989) ISSN: 0008-4212 [Print] Canada
• PMID: 2743209 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• Protein Precursors
• procholecystokinin
• Cholecystokinin
• V-9-M cholecystokinin nonapeptide
• Proglumide

Topics

• Amnesia (psychology)
• Animals
• Avoidance Learning (drug effects)
• Cholecystokinin (administration & dosage, antagonists & inhibitors, pharmacology)
• Electroshock
• Injections, Intraventricular
• Injections, Subcutaneous
• Male
• Memory (drug effects)
• Peptide Fragments (administration & dosage, pharmacology)
• Proglumide (pharmacology)
• Protein Precursors (administration & dosage, pharmacology)
• Rats
• Rats, Inbred Strains
• Time Factors