Influence of T-2 toxin on BCG vaccine efficacy against murine pulmonary tuberculosis.

Abstract

Unvaccinated mice were treated with T-2 toxin either 6 days before or 1 day after exposure to aerosols of virulent Mycobacterium tuberculosis. Mice were also treated with T-2 toxin 6 days before vaccination with Mycobacterium bovis (BCG). There was a T-2 toxin mediated increase in the number of viable vaccine organisms recovered from the spleens of toxin-treated mice at 3 weeks after vaccination, and splenomegaly at post-vaccine weeks 3 through 5. At the seventh week after vaccination, toxin-treated vaccinated, toxin-treated non-vaccinated, vaccinated, and untreated mice were exposed to aerosols of viable M tuberculosis. The number of viable mycobacteria in the lungs was determined at weeks 3, 5, 7, and 9 after pulmonary infection. The number of viable tubercle bacilli recovered from the lungs of vaccinated mice was significantly lower than from unvaccinated mice. However, T-2 toxin-treatment did not alter the vaccine efficacy.

• Authors: R L Ziprin, D N McMurray
• Journal: Veterinary and human toxicology (Vet Hum Toxicol) Vol. 31 Issue 3 Pg. 213-7 (Jun 1989) ISSN: 0145-6296 [Print] United States
• PMID: 2741306 (Publication Type: Journal Article)

Chemical References

• BCG Vaccine
• Sesquiterpenes
• T-2 Toxin

Topics

• Animals
• BCG Vaccine
• Female
• Mice
• Mice, Inbred ICR
• Sesquiterpenes (toxicity)
• Spleen (drug effects)
• T-2 Toxin (toxicity)
• Tuberculosis, Pulmonary (prevention & control)