Studies on the genotoxicity of asataf (acephate), an organophosphate insecticide, in a mammalian in vivo system.

Abstract

The genotoxic potential of asataf (acephate) was evaluated by a battery of in vivo tests: bone marrow chromosome aberrations, micronucleus, sperm-shape abnormality and dominant lethal tests in mice. A significant enhancement in the percentage of chromosome aberrations was noticed in 3 doses, 3 routes and 3 h after asataf treatment of groups of mice as well as in chronic (sub-acute) treatment. A significant difference in the occurrence of micronuclei was found only at the highest dose whereas all the results of the sperm-shape abnormality test were highly significant. In the dominant lethal mutagenicity assay only the result (dead implants) of a single week (3rd) with the higher dose differed significantly from control. On the basis of the present in vivo results in mouse test systems asataf may be considered to be a potential mutagen.

• Authors: B C Behera, S P Bhunya
• Journal: Mutation research (Mutat Res) Vol. 223 Issue 3 Pg. 287-93 (Jul 1989) ISSN: 0027-5107 [Print] Netherlands
• PMID: 2739684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Organothiophosphorus Compounds
• Phosphoramides
• acephate

Topics

• Animals
• Bone Marrow (pathology)
• Genes, Lethal
• In Vitro Techniques
• Insecticides (toxicity)
• Male
• Mice
• Micronucleus Tests
• Organothiophosphorus Compounds (toxicity)
• Phosphoramides
• Spermatozoa (abnormalities, drug effects)