[Effect of the new anti-arrhythmia preparation Bonnecor on the hemodynamics and activity of the ischemic heart].

Abstract

The effect of newly-developed anti-arrhythmia drug Bonnecor compared to that of ethacizin and lidocaine has been studied on anesthetized rats under acute myocardial ischemia. The drugs injected intravenously prior to coronary artery occlusion have been shown to prevent to a great degree the appearance of hemodynamic and functional disturbances of the heart. When compared to control, less reduction in systemic arterial pressure, systolic discharge cardiac output, contractility and heart power were observed. In addition, Bonnecor has been found to have certain advantages over reference drugs.

• Authors: E A Tolmacheva, G G Chichkanov, D D Matsievskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 107 Issue 5 Pg. 588-90 (May 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie novogo antiaritmicheskogo preparata bonnekor na gemodinamiku i deiatel'nost' ishemizirovannogo serdtsa.
• PMID: 2736295 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Dibenzazepines
• Phenothiazines
• Lidocaine
• tiracizine
• ethacizine

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Coronary Disease (drug therapy, physiopathology)
• Dibenzazepines (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Hemodynamics (drug effects)
• Lidocaine (therapeutic use)
• Male
• Myocardial Contraction (drug effects)
• Phenothiazines (therapeutic use)
• Rats