TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.

Abstract

In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).

• Authors: María Salazar, Mar Lorente, Elena García-Taboada, Eduardo Pérez Gómez, David Dávila, Patricia Zúñiga-García, Juana M Flores, Antonio Rodríguez, Zoltan Hegedus, David Mosén-Ansorena, Ana M Aransay, Sonia Hernández-Tiedra, Israel López-Valero, Miguel Quintanilla, Cristina Sánchez, Juan L Iovanna, Nelson Dusetti, Manuel Guzmán, Sheila E Francis, Arkaitz Carracedo, Endre Kiss-Toth, Guillermo Velasco
• Journal: Molecular & cellular oncology (Mol Cell Oncol) 2015 Jul-Sep Vol. 2 Issue 3 Pg. e980134 ISSN: 2372-3556 [Print] United States
• PMID: 27308456 (Publication Type: Journal Article)