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Small molecule targeting miR-34a for cancer therapy.

Abstract
miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer.
AuthorsZhangang Xiao, Yangchao Chen
JournalMolecular & cellular oncology (Mol Cell Oncol) 2015 Jan-Mar Vol. 2 Issue 1 Pg. e977160 ISSN: 2372-3556 [Print] United States
PMID27308410 (Publication Type: Journal Article)

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