An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis.

Abstract

OBJECTIVE:

We evaluated the modified diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by the Japanese Society of Thrombosis and Hemostasis (JSTH) in 108 patients with suspected infectious DIC.

MATERIAL AND METHODS:

The diagnoses of the patients were as follows: DIC (n = 63), pre-DIC (n = 22), and non-DIC (n = 45). The efficacy of the diagnostic criteria for DIC was evaluated using a receiver-operating characteristic analysis.

RESULTS:

Although the area under the curve for global coagulation test (GCT) scores in the diagnosis of "DIC" was high that for the diagnosis of "DIC and pre-DIC" was low, suggesting that the addition of antithrombin (AT), soluble fibrin (SF)/thrombin-AT complex (TAT), and reduced platelet count (PLT) values was required to diagnose "DIC and pre-DIC." Using GCT score with the AT, SF/TAT, and reduced PLT values, the cutoff value of the DIC score for the diagnosis of "DIC and pre-DIC" was 5 points.

DISCUSSION AND CONCLUSION:

The modified JSTH's diagnostic criteria for DIC, which used the GCT score and the reduced PLT, AT, and TAT/SF values, were useful for diagnosing "DIC and pre-DIC."

• Authors: Takumi Aota, Hideo Wada, Yoshiki Yamashita, Takeshi Matsumoto, Kohshi Ohishi, Kei Suzuki, Hiroshi Imai, Masanobu Usui, Shuji Isaji, Hidesaku Asakura, Kohji Okamoto, Naoyuki Katayama
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 23 Issue 6 Pg. 579-584 (Sep 2017) ISSN: 1938-2723 [Electronic] United States
• PMID: 27301403 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Antithrombins
• antithrombin III-protease complex
• Antithrombin III
• Fibrin
• Peptide Hydrolases

Topics

• Aged
• Aged, 80 and over
• Antithrombin III
• Antithrombins (blood)
• Disseminated Intravascular Coagulation (diagnosis)
• Female
• Fibrin (analysis)
• Humans
• Japan
• Male
• Middle Aged
• Peptide Hydrolases (blood)
• Platelet Count
• Practice Guidelines as Topic (standards)
• ROC Curve
• Severity of Illness Index