Endometrial hyperplasia has been considered as a
hormone dependent lesion. Besides atypical genital
bleeding, the possibility of
endometrial carcinoma is also of significance. In this study, we administered 400mg daily of
Danazol in 29 cases or 20mg daily of
tamoxifen in 20 cases, respectively, for climacteric or postmenopausal women with different types of
endometrial hyperplasia, and discussed their effect. Genital
bleeding due to
hyperplasia disappeared within 10-28 days in the
danazol group and within 7-30 days in the
tamoxifen group. In the latter group also, 2 climacteric women experienced menopause. The tortuous gland of
hyperplasia became smaller and rounder. At the end of the treatment the glandular epithelium was low and showed a very poor secretory phase. The nuclei mitosis both in the glandular and stromal cells disappeared. The regression of
hyperplasia was obtained after 1, 3, 6 months of
danazol therapy in 37.9%, 72.4%, 93.1% and with
tamoxifen therapy in 65%, 80%, 90% respectively, without undesirable side effects. In conclusion, the control of the
endometrial hyperplasia with
danazol and
tamoxifen was suggested, and the results of the use of the suggested method were no further occurrence and/or progression of the disease. Both of the drugs were effective and safe alternative
therapy for
endometrial hyperplasia to
progesterone.