[Diagnostic usefulness and limitation of measuring pancreatic cancer associate antigen, SPan-1, in patients with pancreatic cancer].

Abstract

Serum levels of SPan-1 were determined in patients with various gastrointestinal cancers including pancreatic cancer and benign disorders, as well as from healthy subjects, by using a newly developed SPan-1 antigen immunoradiometric assay (SPan-1 RIABEAD, Dainabott). In addition, usefulness of diagnosis for pancreatic cancer by determination of Serum SPan-1 antigen was compared with that of other tumor markers such as CA 19-9, DU-PAN 2, CA 50, CEA and elastase 1 in the same patients. Serum SPan-1 antigen levels in healthy controls ranged from 0 to 156 U/ml with a mean of 7.7 U/ml (+/- 15.0, 2 S.D). Thirty U/ml of serum SPan-1 antigen levels was set as the cut-off value, and 98.9% of healthy controls were within this cut-off value (30 U/ml). Serum SPan-1 antigen levels in pancreatic cancer were distributed from 0-353, 900 U/ml with a mean of 14,466 U/ml (+/- 16.616 SD). Sensitivity of SPan-1 antigen in pancreatic cancer was 81.9%, which was the highest among gastrointestinal cancers, and eight of nine pancreatic cancer patients with stage II showed above normal limits (30 U/ml). Although serum SPan-1 antigen levels in biliary tract cancer and liver cirrhosis showed a high percentage (70.3%, 56.8%), the mean values of SPan-1 antigen levels in these groups were 477 U/ml and 62.8 U/ml, respectively, which was lower than that of pancreatic cancer. False positive ratio of SPan-1 antigen in benign pancreatic disease was lower than that of CA 19-9. Also, comparative studies of SPan-1 antigen and various tumor markers between pancreatic cancer and benign gastrointestinal diseases revealed that SPan-1 antigen showed the highest sensitivity and accuracy in diagnosis for pancreatic cancer among other tumor markers. From these results, measurement of SPan-1 antigen appeared to be the most useful marker in the diagnosis of pancreatic cancer.

• Authors: K Satake, Y S Chung, K Umeyama, T Takeuchi, Y S Kim
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 4 Pt 2-1 Pg. 1139-46 (Apr 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2730018 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Carcinoembryonic Antigen
• DU-PAN-2 antigen, human
• pancreatic associated antigen, SPan-1
• Pancreatic Elastase

Topics

• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Biomarkers, Tumor (blood)
• Carcinoembryonic Antigen (analysis)
• Humans
• Pancreatic Elastase (blood)
• Pancreatic Neoplasms (blood, immunology)