Abstract |
We evaluated the efficacy of buparvaquone in eliminating Babesia equi of European origin in carrier horses and in experimentally infected splenectomized ponies. When administered at the rate of 2.5 mg/kg of body weight, IM, 4 times at 96-hour intervals, buparvaquone was effective in eliminating B equi carrier infection in 1 horse. Such results could not be repeated at the same dosage or at 3.5 or 5 mg/kg, IM. Buparvaquone given at the rate of 4 to 6 mg/kg IV and/or IM was therapeutically effective in 4 of 5 acute B equi infections in splenectomized ponies. The treated ponies became carriers.
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Authors | J L Zaugg, V M Lane |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 50
Issue 5
Pg. 782-5
(May 1989)
ISSN: 0002-9645 [Print] United States |
PMID | 2729726
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiprotozoal Agents
- Naphthoquinones
- buparvaquone
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Topics |
- Animals
- Antiprotozoal Agents
(therapeutic use)
- Babesiosis
(drug therapy)
- Carrier State
(drug therapy, veterinary)
- Horse Diseases
(drug therapy)
- Horses
- Male
- Naphthoquinones
(therapeutic use)
- Splenectomy
(veterinary)
- Time Factors
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