Sarcoidosis following adjuvant high-dose methotrexate therapy for osteosarcoma.

Abstract

A patient who had undergone amputation and adjuvant chemotherapy with methotrexate doxorubicin hydrochloride for osteosarcoma of the femur later developed granulomatous hilar and paratracheal lymphadenopathy and multiple pulmonary nodules. Biopsy of the nodules showed noncaseating granulomas typical of sarcoidosis. Hilar adenopathy and granulomatous pneumonitis have been reported following methotrexate therapy, but a roentgenographic pattern of isolated, discrete pulmonary nodules has not been described. Treatment with immunosuppressive chemotherapy may have inhibited the development of sarcoidosis, which became manifest only after cessation of the chemotherapy.

• Authors: A Sybert, T P Butler
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 138 Issue 3 Pg. 488-9 (Mar 1978) ISSN: 0003-9926 [Print] United States
• PMID: 272865 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Methotrexate

Topics

• Adolescent
• Amputation, Surgical
• Femoral Neoplasms (drug therapy, surgery)
• Humans
• Male
• Methotrexate (administration & dosage, therapeutic use)
• Osteosarcoma (drug therapy, surgery)
• Radiography
• Sarcoidosis (diagnostic imaging, etiology, immunology)