Abstract |
Centella asiatica was extracted by methanol. The assay content of triterpenes in the extract was 0.12 % asiatic acid, 0.54 % madecassic acid, 0.25 % asiaticoside and 1.02 % madecassoside. The extract was complexed with hydroxypropyl-β- cyclodextrin (HP-β-CD) and formulated with Eudragit E100, glycerol, PEG 400, copovidone, ethanol and purified water. A clear yellowish solution (F1-F8) was obtained. The formulations had a pH of 5.5-6.0 with viscosity in the range of 20-60 mPa s, surface tension 20.3-24.6 mN m-1 and contact angle less than 20°. The amount of PEG 400 and copovidone affected the film and spreadability. The content of triterpenes in the spray formulation was close to 100 % compared to triterpenes in the extract. The skin irritation study indicated that the formulation was non-irritating in a rat model. An in vivo excision wound healing model showed that wound excision was completely healed after 14 days.
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Authors | Somchai Sawatdee, Kanuengnit Choochuay, Wirot Chanthorn, Teerapol Srichana |
Journal | Acta pharmaceutica (Zagreb, Croatia)
(Acta Pharm)
Vol. 66
Issue 2
Pg. 233-44
(Jun 01 2016)
ISSN: 1846-9558 [Electronic] Poland |
PMID | 27279066
(Publication Type: Journal Article)
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Chemical References |
- Aerosols
- Centella asiatica extract
- Excipients
- Plant Extracts
- Pyrrolidines
- Triterpenes
- Vinyl Compounds
- poly(vinylpyrrolidone-co-vinyl-acetate)
- Polyethylene Glycols
- polyethylene glycol 400
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Topics |
- Administration, Cutaneous
- Aerosols
- Animals
- Centella
(chemistry)
- Disease Models, Animal
- Drug Compounding
- Excipients
(chemistry)
- Male
- Phytotherapy
- Plant Extracts
(administration & dosage, chemistry, isolation & purification)
- Plants, Medicinal
- Polyethylene Glycols
(chemistry)
- Pyrrolidines
(chemistry)
- Rats, Wistar
- Surgical Wound
(drug therapy, pathology)
- Time Factors
- Triterpenes
(administration & dosage, chemistry, isolation & purification)
- Vinyl Compounds
(chemistry)
- Wound Healing
(drug effects)
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