[Effect of 1-alpha oxyvitamin D3 on bone tissue in systemic osteoporosis].

Abstract

Prolonged administration of oxydevit (I alpha OH D3), a synthetic analogue of the active metabolite of vitamin D (I alpha 25, (OH)2D3) in patients with systemic osteoporosis inhibited the progress of the process. Abatement of the pain syndrome and increase in physical activity were accompanied by stabilization of the roentgenologic picture and of such parameters of the bone tissue as volume density of the spongy bone and thickness of the trabeculae. The mechanism of action of the drug is not quite clear, but importance is attached to the influence of the drug on the absorption of calcium from the intestines and to persistent normalization of the level of calcium in the blood. Taking into consideration the course of such disease as systemic osteoporosis, the inhibitory impact should be regarded as achievement of therapeutic effect.

• Authors: S S Rodionova, S T Zatsepin, V N Shvets
• Journal: Ortopediia travmatologiia i protezirovanie (Ortop Travmatol Protez) Issue 2 Pg. 37-40 (Feb 1989) ISSN: 0030-5987 [Print] Russia (Federation)
• Vernacular Title: Vliianie 1-al'fa oksivitamina D3 na kostnuiu tkan' pri sistemnom osteoporoze.
• PMID: 2726218 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxycholecalciferols
• 1-hydroxyprevitamin D3
• Calcifediol

Topics

• Adult
• Aged
• Bone and Bones (drug effects, physiopathology)
• Calcifediol (analogs & derivatives, therapeutic use)
• Female
• Humans
• Hydroxycholecalciferols (therapeutic use)
• Menopause
• Middle Aged
• Osteogenesis (drug effects)
• Osteoporosis (drug therapy, physiopathology)