Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase.

Abstract	Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian cancer remains elusive, and the identity of SOX3 in ovarian cancer initiation, progression, and the related underlying mechanism is unknown. In this study, we showed that SOX3 expression increased from benign and borderline to malignant ovarian tumors. Subsequently, we found that overexpression of SOX3 in EOC cells promoted proliferation, migration, and invasion, while restrained apoptosis and adhesion of ovarian cancer cells. In contrast, silencing of SOX3 gained the opposite results. Finally, we discovered SOX3 targeted Src kinase in EOC cells. These data imply that SOX3, acting as an oncogene in EOC, is not only a crucial factor in the carcinogenesis but also a promising therapeutic target for EOC.
Authors	Qin Yan, Fangyuan Wang, Yi Miao, Xiaomei Wu, Mingzhu Bai, Xiaowei Xi, Youji Feng
Journal	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 37 Issue 9 Pg. 12263-12271 (Sep 2016) ISSN: 1423-0380 [Electronic] Netherlands
PMID	27251670 (Publication Type: Journal Article)
Chemical References	SOX3 protein, human SOXB1 Transcription Factors src-Family Kinases
Topics	Adult Aged Aged, 80 and over Apoptosis (genetics) Blotting, Western Carcinoma, Ovarian Epithelial Cell Adhesion (genetics) Cell Line Cell Line, Tumor Cell Movement (genetics) Cell Proliferation (genetics) Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Microscopy, Confocal Middle Aged Neoplasms, Glandular and Epithelial (genetics, metabolism, pathology) Oncogenes (genetics) Ovarian Neoplasms (genetics, metabolism, pathology) RNA Interference Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors (genetics, metabolism) Young Adult src-Family Kinases (genetics, metabolism)

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