Impact of Distal Protection with Filter-Type Device on Long-term Outcome after Percutaneous Coronary Intervention for Acute Myocardial Infarction: Clinical Results with Filtrap®.

Abstract

AIM:

Although distal embolization during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) deteriorates cardiac function, whether distal protection (DP) can improve prognosis is still controversial. We investigated whether a filter-type DP device, Filtrap®, could improve long-term outcomes after PCI for AMI.

METHOD:

We studied 164 patients (130 men, mean age: 65.7 years) who underwent PCI. Patients were divided into two groups based on the use of Filtrap®. The occurrence of congestive heart failure (CHF) and major adverse cardiac events (MACE) defined as cardiac death, recurrent AMI, and target vessel revascularization were compared.

RESULT:

Between DP (n=53, 41 men, mean age: 65.5 years) and non-DP (n=111, 89 men, mean age: 65.8 years) groups, although there was significantly greater plaque area in the DP group than in the non-DP group, there were no significant differences in coronary reperfusion flow after PCI. Interestingly, patients with CHF in the non-DP group exhibited a higher CK level than those in the DP group. During a 2-year follow-up period, cumulative CHF was significantly lower in the DP group than in the non-DP group (log-rank p=0.018), and there was no significant difference in the MACE rate (log-rank p=0.238). The use of DP device could not predict MACE, but could predict CHF by multivariate analysis (odds ratio=0.099, 95% CI: 0.02-0.42, p=0.005).

CONCLUSION:

These results demonstrate that favorable clinical outcomes could be achieved by the filter-type DP device in AMI, particularly in patients with CHF.

• Authors: Ryota Teramoto, Kenji Sakata, Kenji Miwa, Takao Matsubara, Toshihiko Yasuda, Masaru Inoue, Hirofumi Okada, Honin Kanaya, Masa-Aki Kawashiri, Masakazu Yamagishi, Kenshi Hayashi
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 23 Issue 12 Pg. 1313-1323 (Dec 01 2016) ISSN: 1880-3873 [Electronic] Japan
• PMID: 27251330 (Publication Type: Journal Article)

Topics

• Aged
• Angioplasty, Balloon, Coronary (methods)
• Electrocardiography (methods)
• Embolic Protection Devices (statistics & numerical data)
• Female
• Filtration (instrumentation)
• Heart Failure (diagnosis, etiology, prevention & control)
• Humans
• Male
• Middle Aged
• Myocardial Infarction (surgery)
• Percutaneous Coronary Intervention (adverse effects)
• Prognosis