Antitumor activity in the acridine series.

Abstract

The antitumor effect against experimental tumors in mice of three acridine derivatives analog or homolog of N-[4'-(9-acridinylamino)-3'-methoxyphenyl]-methanesulfonamide has been investigated. The 3,6-bis-dimethylamino analog (DAMSA) showed important antitumor effect in murine leukemias and moderate effect in a solid tumor, the M5076 reticulosarcoma. The body weight loss of the treated mice was always within an acceptable range when 100 mg/kg were administered under the conditions of the experiment. However, a systemic toxic effect could be observed when 200 mg/kg were used. This preliminary data may be considered as an important step in the development of new acridine analogs with a different spectrum of antitumor activity.

• Authors: R R Smolders, G Atassi, N Voglet, A Waefelaer
• Journal: Journal de pharmacie de Belgique (J Pharm Belg) 1989 Jan-Feb Vol. 44 Issue 1 Pg. 11-6 ISSN: 0047-2166 [Print] Belgium
• PMID: 2724046 (Publication Type: Journal Article)

Chemical References

• Acridines
• Antineoplastic Agents

Topics

• Acridines (pharmacology)
• Animals
• Antineoplastic Agents
• Mice