Abstract |
The metabolism of [19-3H3] androstenedione by human placental microsomes was studied in vitro by radiometric analysis which distinguishes between 19-hydroxylation and elimination of the C-19 carbon. The ratio of the metabolic products tritiated water/tritiated formic acid is significantly greater for microsomes from patients with pregnancy hypertension when compared with normotensive pregnant women. This indicates that aromatization (2-hydroxylation) is deficient in pregnancy hypertension.
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Authors | M E Hähnel, J D Martin, C A Michael, R Hähnel |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 181
Issue 1
Pg. 103-8
(Apr 28 1989)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 2721001
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Androstenedione
(metabolism)
- Female
- Humans
- Hypertension
(metabolism)
- Microsomes
(metabolism)
- Oxidation-Reduction
- Placenta
(metabolism)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(metabolism)
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