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Metabolism of androstenedione by placental microsomes in pregnancy hypertension.

Abstract
The metabolism of [19-3H3]androstenedione by human placental microsomes was studied in vitro by radiometric analysis which distinguishes between 19-hydroxylation and elimination of the C-19 carbon. The ratio of the metabolic products tritiated water/tritiated formic acid is significantly greater for microsomes from patients with pregnancy hypertension when compared with normotensive pregnant women. This indicates that aromatization (2-hydroxylation) is deficient in pregnancy hypertension.
AuthorsM E Hähnel, J D Martin, C A Michael, R Hähnel
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 181 Issue 1 Pg. 103-8 (Apr 28 1989) ISSN: 0009-8981 [Print] Netherlands
PMID2721001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Androstenedione
Topics
  • Androstenedione (metabolism)
  • Female
  • Humans
  • Hypertension (metabolism)
  • Microsomes (metabolism)
  • Oxidation-Reduction
  • Placenta (metabolism)
  • Pregnancy
  • Pregnancy Complications, Cardiovascular (metabolism)

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