[Peripheral cholinolytic action--one of the effects of sidnofen].

Abstract

Intravenous bolus injection of sydnophen (0.002-20 micrograms/kg) resulted in decrease or complete abolition of bradycardia induced by electrical stimulation of vagal peripheral end of anesthetized cats. The cholinolytic effects are dose-dependent. The small dose of sydnophen (0.002 micrograms/kg) which wasn't able to cause any alteration of EEG, heart rate and arterial pressure induced decrease of vagal bradycardia.

• Authors: G E Samonina, E V Mandriko
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 107 Issue 4 Pg. 449-51 (Apr 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Perifericheskoe kholinoliticheskoe deĭstvie--odin iz éffektov sidnofena.
• PMID: 2720163 (Publication Type: English Abstract, Journal Article)

Chemical References

• Oxadiazoles
• Parasympatholytics
• Sydnones
• sydnophen

Topics

• Animals
• Blood Pressure (drug effects)
• Cats
• Dose-Response Relationship, Drug
• Electric Stimulation
• Electrocardiography
• Electroencephalography
• Heart Rate (drug effects)
• Oxadiazoles (pharmacology)
• Parasympathetic Nervous System (drug effects)
• Parasympatholytics (pharmacology)
• Sydnones (pharmacology)
• Vagus Nerve (physiology)