HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Paroxysmal supraventricular tachycardia: experience with propafenone.

Abstract
The authors studied the efficacy of intravenous (IV) (1.5-2 mg/kg) and oral propafenone (450 to 900 mg/day) in 16 patients with paroxysmal, sustained, recurrent supraventricular tachycardia (SVT). In 5 patients IV propafenone was not given, because of intolerant SVT. Nine patients had Wolff-Parkinson-White syndrome. IV propafenone immediately stopped and prevented reinduction of SVT in 9/11 patients. Oral propafenone prevented SVT induction in 3 of 5 patients. In the 9 patients responsive to IV propafenone, oral propafenone was effective: in particular, in 6 patients SVT tachycardia was not induced by serial transesophageal pacings, and in the remaining 3 patients the arrhythmia was still induced but was slower and of brief duration (3-5 seconds). In 11/12 patients responsive to oral propafenone the minimum effective dosage in preventing the induction of the arrhythmia was 600 mg/day. In only 1 patient was the dose of 450 mg/day equally effective. Propafenone administration was not associated with major side effects. In conclusion, propafenone is very effective in the control of paroxysmal supraventricular tachycardia; intravenous propafenone can predict the efficacy of oral therapy.
AuthorsV Santinelli, M De Paola, P Turco, D Smimmo, M Chiariello
JournalAngiology (Angiology) Vol. 40 Issue 6 Pg. 563-8 (Jun 1989) ISSN: 0003-3197 [Print] United States
PMID2719341 (Publication Type: Journal Article)
Chemical References
  • Propafenone
Topics
  • Administration, Oral
  • Adult
  • Electrophysiology
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Propafenone (adverse effects, therapeutic use)
  • Tachycardia, Paroxysmal (drug therapy, physiopathology)
  • Tachycardia, Supraventricular (drug therapy, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: