[Immunologic disorders in cerebrovascular lesions associated with livedo (Sneddon's syndrome)].

Abstract

In combined immunological investigation of 24 patients with Sneddon syndrome, 16 showed the decreased content of T-lymphocytes and theophylline-sensitive cells, increased content of B-lymphocytes, increased levels of IgM and circulating immune complexes. In 80% of the patients the leukocyte adherence inhibition test has revealed the blood cell sensitization against nervous tissue antigens, basic myelin protein of purified protein derivative. The data suggest the participation of autoimmune mechanisms in the Sneddon syndrome pathogenesis.

• Authors: L A Kalashnikova, I G Zhirnova, L V Komel'kova
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 89 Issue 1 Pg. 31-4 ( 1989) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Immunologicheskie narusheniia pri sosudistom porazhenii mozga, sochetaiushchemsia s livedo (sindrom Sneddona).
• PMID: 2718660 (Publication Type: English Abstract, Journal Article)

Topics

• Adult
• Cerebrovascular Disorders (immunology)
• Female
• Humans
• Immunity
• Male
• Middle Aged
• Skin Diseases (immunology)
• Syndrome