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[Dependence of the radioprotective effect of beta-mercaptoethylamine on the thiol level of the outer cell membrane].

Abstract
In experiments with Ehrlich ascites tumor cells with the use of a specific thiol blocker, 6,6'-dithiodinicotinic acid, it was shown that thiols of a cell plasmic membrane are necessary for the radioprotective effect of mercaptoethylamine to be realized.
AuthorsM M Konstantinova, G V Dontsova, N M Koroleva
JournalRadiobiologiia (Radiobiologiia) 1989 Mar-Apr Vol. 29 Issue 2 Pg. 280-2 ISSN: 0033-8192 [Print] Russia (Federation)
Vernacular TitleZavisimost' radiozashchitnogo éffekta beta-merkaptoétilamina ot urovnia tiolov naruzhnoĭ kletochnoĭ membrany.
PMID2717725 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Mercaptoethylamines
  • Nicotinic Acids
  • Radiation-Protective Agents
  • Sulfhydryl Compounds
  • Sulfhydryl Reagents
  • 6,6'-dithiodinicotinic acid
Topics
  • Animals
  • Carcinoma, Ehrlich Tumor (metabolism, radiotherapy)
  • Cell Membrane (drug effects, metabolism, radiation effects)
  • Chromosome Aberrations
  • Drug Evaluation, Preclinical
  • Drug Interactions
  • Mercaptoethylamines (therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Nicotinic Acids (pharmacology)
  • Radiation-Protective Agents
  • Sulfhydryl Compounds (metabolism)
  • Sulfhydryl Reagents (pharmacology)
  • Time Factors
  • Tumor Cells, Cultured

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