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Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment.

Abstract
Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf(4+)) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf(4+) with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions.
AuthorsJingjing Liu, Yu Yang, Wenwen Zhu, Xuan Yi, Ziliang Dong, Xiaona Xu, Meiwan Chen, Kai Yang, Guang Lu, Lixin Jiang, Zhuang Liu
JournalBiomaterials (Biomaterials) Vol. 97 Pg. 1-9 (08 2016) ISSN: 1878-5905 [Electronic] Netherlands
PMID27155362 (Publication Type: Journal Article)
CopyrightCopyright © 2016 Elsevier Ltd. All rights reserved.
Chemical References
  • 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin cobalt
  • Metal-Organic Frameworks
  • Metalloporphyrins
  • Polyethylene Glycols
  • Hafnium
Topics
  • Animals
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Hafnium (chemistry)
  • Humans
  • Injections, Intravenous
  • Metal-Organic Frameworks (chemistry)
  • Metalloporphyrins (therapeutic use)
  • Mice
  • Mice, Inbred BALB C
  • NIH 3T3 Cells
  • Nanostructures (chemistry, ultrastructure)
  • Neoplasms (drug therapy, pathology, radiotherapy)
  • Photochemotherapy
  • Polyethylene Glycols (chemistry)

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