Abstract |
Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf(4+)) and tetrakis (4-carboxyphenyl) porphyrin ( TCPP). In such Hf- TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy ( PDT), Hf(4+) with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti- tumor effect. Importantly, Hf- TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions.
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Authors | Jingjing Liu, Yu Yang, Wenwen Zhu, Xuan Yi, Ziliang Dong, Xiaona Xu, Meiwan Chen, Kai Yang, Guang Lu, Lixin Jiang, Zhuang Liu |
Journal | Biomaterials
(Biomaterials)
Vol. 97
Pg. 1-9
(08 2016)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 27155362
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Chemical References |
- 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin cobalt
- Metal-Organic Frameworks
- Metalloporphyrins
- Polyethylene Glycols
- Hafnium
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Topics |
- Animals
- Cell Line, Tumor
- Combined Modality Therapy
- Hafnium
(chemistry)
- Humans
- Injections, Intravenous
- Metal-Organic Frameworks
(chemistry)
- Metalloporphyrins
(therapeutic use)
- Mice
- Mice, Inbred BALB C
- NIH 3T3 Cells
- Nanostructures
(chemistry, ultrastructure)
- Neoplasms
(drug therapy, pathology, radiotherapy)
- Photochemotherapy
- Polyethylene Glycols
(chemistry)
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