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New high O2 carrying perfluorochemical emulsions: toxicity, radiosensitivity of GM-CFC and development of metastases in mice.

Abstract
The effects of two new concentrated perfluorochemical emulsions based on F-66E and PFOB, which carry significantly more oxygen than Fluosol-DA 20%, were tested on normal tissues (toxicity and radiation response) and on the development of metastases from Lewis Lung Carcinoma (3LL) in female C57 BL/6 mice. Twenty one days after injection of F-66E or PFOB emulsions (15 ml/kg body weight), the spleen and liver weights were significantly increased but had returned to normal after 2-3 months. Splenomegaly already observed in 3LL bearing mice was significantly increased by F-66E emulsion injection. The radiosensitivity of GM-CFC was not altered when unanesthetized GM-CFC was not altered when unanesthetized mice were pretreated with F-66E emulsions and/or carbogen 1 hr prior to and during irradiation. The rate of tumor take and the period before detection of tumors were not modified when an emulsion of F-66E was injected simultaneously or 10 days after 3LL cells. Mean survival of mice, and the number of metastases on lung surfaces were similar in F-66E injected mice and control mice.
AuthorsE Lartigau, C Thomas, M Le Blanc, J Riess, D Long, C Long, E P Malaise, M Guichard
JournalInternational journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 16 Issue 5 Pg. 1153-6 (May 1989) ISSN: 0360-3016 [Print] United States
PMID2715062 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluorocarbons
  • Hydrocarbons, Brominated
  • bis(perfluoro-n-hexyl)-1,2-ethylene
  • perflubron
Topics
  • Animals
  • Female
  • Fluorocarbons (toxicity)
  • Hematopoietic Stem Cells (drug effects, radiation effects)
  • Hydrocarbons, Brominated
  • Lung Neoplasms (secondary)
  • Mice
  • Mice, Inbred C57BL
  • Organ Size (drug effects)
  • Radiation Tolerance (drug effects)

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