Abstract |
The effects of two new concentrated perfluorochemical emulsions based on F-66E and PFOB, which carry significantly more oxygen than Fluosol-DA 20%, were tested on normal tissues (toxicity and radiation response) and on the development of metastases from Lewis Lung Carcinoma (3LL) in female C57 BL/6 mice. Twenty one days after injection of F-66E or PFOB emulsions (15 ml/kg body weight), the spleen and liver weights were significantly increased but had returned to normal after 2-3 months. Splenomegaly already observed in 3LL bearing mice was significantly increased by F-66E emulsion injection. The radiosensitivity of GM-CFC was not altered when unanesthetized GM-CFC was not altered when unanesthetized mice were pretreated with F-66E emulsions and/or carbogen 1 hr prior to and during irradiation. The rate of tumor take and the period before detection of tumors were not modified when an emulsion of F-66E was injected simultaneously or 10 days after 3LL cells. Mean survival of mice, and the number of metastases on lung surfaces were similar in F-66E injected mice and control mice.
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Authors | E Lartigau, C Thomas, M Le Blanc, J Riess, D Long, C Long, E P Malaise, M Guichard |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 16
Issue 5
Pg. 1153-6
(May 1989)
ISSN: 0360-3016 [Print] United States |
PMID | 2715062
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorocarbons
- Hydrocarbons, Brominated
- bis(perfluoro-n-hexyl)-1,2-ethylene
- perflubron
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Topics |
- Animals
- Female
- Fluorocarbons
(toxicity)
- Hematopoietic Stem Cells
(drug effects, radiation effects)
- Hydrocarbons, Brominated
- Lung Neoplasms
(secondary)
- Mice
- Mice, Inbred C57BL
- Organ Size
(drug effects)
- Radiation Tolerance
(drug effects)
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