Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety.

Abstract

Low levels of serum vitamin D are common in patients with mood disorders and stroke. It has been shown that low levels of serum vitamin D indicate a risk of depression in post-stroke subjects. Our aim was to determine the relationship between vitamin D and post-stroke anxiety (PSA).A consecutive series of 226 first acute ischemic stroke patients were recruited and followed up for 1 month. Serum levels of vitamin D were measured within 24 hours of admission. Patients with significant clinical symptoms of anxiety and a Hamilton anxiety scale score >7 were diagnosed as having PSA. In addition, 100 healthy subjects were recruited as controls and underwent measurements of serum vitamin D.A total of 60 patients (26.55%) showed anxiety at 1 month. Both PSA patients and non-PSA patients had lower serum levels of vitamin D than healthy subjects. A significant relationship was found between PSA and serum levels of vitamin D. Low serum levels of vitamin D (≤38.48 nmol/L) were independently associated with the development of PSA (OR: 2.49, 95% CI: 1.21-5.13, P = 0.01).Serum vitamin D status is related to the occurrence of anxiety in post-stroke patients and may be an independent risk factor of PSA after 1 month.

• Authors: Chaowen Wu, Wenwei Ren, Jianhua Cheng, Beilei Zhu, Qianqian Jin, Liping Wang, Cao Chen, Lin Zhu, Yaling Chang, Yingying Gu, Jiyun Zhao, Dezhao Lv, Bei Shao, Shunkai Zhang, Jincai He
• Journal: Medicine (Medicine (Baltimore)) Vol. 95 Issue 18 Pg. e3566 (May 2016) ISSN: 1536-5964 [Electronic] United States
• PMID: 27149477 (Publication Type: Journal Article)

Chemical References

• Vitamins
• Vitamin D

Topics

• Anxiety (blood, etiology)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Statistics, Nonparametric
• Stroke (blood, complications, psychology)
• Vitamin D (blood)
• Vitamin D Deficiency (blood, complications)
• Vitamins (blood)