Abstract |
The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.
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Authors | B B Ba, A Iliadis, A Durand, Y Berger, J Necciari, J P Cano |
Journal | Fundamental & clinical pharmacology
(Fundam Clin Pharmacol)
Vol. 3
Issue 1
Pg. 11-7
( 1989)
ISSN: 0767-3981 [Print] England |
PMID | 2714728
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Anxiety Agents
- Benzodiazepinones
- Benzodiazepines
- ethyl loflazepate
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Topics |
- Administration, Oral
- Adult
- Aged
- Anti-Anxiety Agents
- Benzodiazepines
- Benzodiazepinones
(pharmacokinetics)
- Female
- Humans
- Kidney Failure, Chronic
(metabolism)
- Male
- Middle Aged
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