Use of caffeine in the treatment of apnea associated with the Arnold-Chiari malformation.

The occurrence of significant apnea has been reported in infants with Arnold-Chiari malformation (ACM). We report 1 infant with ACM and severe apnea treated with caffeine therapy. There was a marked decrease in apnea frequency, less variability in breathing patterns, and a shift to the left of the CO2 response curve with caffeine. Our findings in 1 infant suggest that caffeine may be an effective adjunct in the treatment of apnea associated with ACM.
AuthorsJ M Davis, R Zinman, J V Aranda
JournalDevelopmental pharmacology and therapeutics (Dev Pharmacol Ther) Vol. 12 Issue 2 Pg. 70-3 ( 1989) ISSN: 0379-8305 [Print] SWITZERLAND
PMID2714160 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Caffeine
  • Arnold-Chiari Malformation (complications)
  • Caffeine (therapeutic use)
  • Humans
  • Infant, Newborn
  • Male
  • Sleep Apnea Syndromes (drug therapy, etiology)

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