Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages.
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| Abstract |
Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
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| Authors | Laura Unverdorben, Thomas Haufe, Laura Santoso, Simone Hofmann, Udo Jeschke, Stefan Hutter |
| Journal | International journal of molecular sciences (Int J Mol Sci) Vol. 17 Issue 5 (Apr 28 2016) ISSN: 1422-0067 [Electronic] Switzerland |
| PMID | 27136536 (Publication Type: Journal Article) |
| Chemical References |
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