Covalent coupling of sugars to liposomes.

Abstract

A procedure is described for the covalent coupling of p-aminophenyl-alpha-D-mannopyranoside, in the presence of carbodiimide, to a derivative of phosphatidylethanolamine (N-glutarylphosphatidylethanolamine) incorporated into the bilayers of multilamellar liposomes prepared by the dehydration-rehydration method. It appears that much of the phospholipid derivative exposed on the surface of the outer liposomal bilayer interacts with the aminosugar. The procedure is simple, does not destabilize liposomes and could be applied to other receptor-specific aminosugars.

• Authors: V Weissig, J Lasch, G Gregoriadis
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1003 Issue 1 Pg. 54-7 (May 15 1989) ISSN: 0006-3002 [Print] Netherlands
• PMID: 2713394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Liposomes
• Mannose

Topics

• Binding Sites
• Chemical Phenomena
• Chemistry
• Liposomes
• Mannose
• Permeability