Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Abstract

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

• Authors: Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L Burness, Ebrahim Azizi, Diane M Simeone, Max S Wicha, Jinsang Kim, Sunitha Nagrath
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 28 Issue 24 Pg. 4891-7 (Jun 2016) ISSN: 1521-4095 [Electronic] Germany
• PMID: 27115557 (Publication Type: Journal Article)
• Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antibodies
• Oxides
• Polymers
• Graphite

Topics

• Antibodies (chemistry)
• Cell Separation (methods)
• Cell Survival
• Graphite (chemistry)
• Humans
• MCF-7 Cells
• Microfluidics (methods)
• Neoplasms (blood, pathology)
• Neoplastic Cells, Circulating (pathology)
• Oxides (chemistry)
• Polymers (chemistry)
• Temperature